Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
JANG HENGSTLER, D Utesch, P Steinberg… - Drug metabolism …, 2000 - Taylor & Francis
The use of primary hepatocytes is now well established for both studies of drug metabolism
and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for …
and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for …
[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
…, CG Woods, JJ Xu, KM Yarborough, JG Hengstler - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
…, M Vetter, A Weise, T Liehr, M Brulport, JG Hengstler… - Gut, 2009 - gut.bmj.com
Objective: The hepatic integration of human adipose tissue derived mesenchymal stem cells
(hAT-MSCs) in vivo with or without prior differentiation to hepatocyte-like cells in vitro was …
(hAT-MSCs) in vivo with or without prior differentiation to hepatocyte-like cells in vitro was …
Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers
…, MM Dollinger, W Schormann, J Walldorf, JG Hengstler… - Gut, 2007 - gut.bmj.com
Aims: At present, clinical success of hepatocyte transplantation as an alternative to whole
liver transplantation is hampered by the limited availability of suitable donor organs for the …
liver transplantation is hampered by the limited availability of suitable donor organs for the …
[HTML][HTML] Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
Integration of multiple three-dimensional microtissues into microfluidic networks enables
new insights in how different organs or tissues of an organism interact. Here, we present a …
new insights in how different organs or tissues of an organism interact. Here, we present a …
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in …
…, E LeCluyse, GMM Groothuis, JG Hengstler - Drug metabolism …, 2007 - Taylor & Francis
This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …
The humoral immune system has a key prognostic impact in node-negative breast cancer
…, E Steiner, A Puhl, H Pilch, HA Lehr, JG Hengstler… - Cancer research, 2008 - AACR
Estrogen receptor (ER) expression and proliferative activity are established prognostic
factors in breast cancer. In a search for additional prognostic motifs, we analyzed the gene …
factors in breast cancer. In a search for additional prognostic motifs, we analyzed the gene …
Molecular modes of action of artesunate in tumor cell lines
…, E Gebhart, P Rauch, HO Weber, JG Hengstler… - Molecular …, 2003 - ASPET
A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55
cancer cell lines of the US National Cancer Institute (NCI). The 50% inhibition concentrations (…
cancer cell lines of the US National Cancer Institute (NCI). The 50% inhibition concentrations (…
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
…, A Allione, G Cancel-Tassin, S Selinski, JG Hengstler… - Nature …, 2010 - nature.com
We conducted a multi-stage, genome-wide association study of bladder cancer with a
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …
[HTML][HTML] The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery
The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …
catalog of high-resolution reference epigenomes of major primary human cell types. The …