High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by
EXponential Enrichment), a method for aptamer discovery, with massively parallel sequencing …

Motivation: Systematic Evolution of Ligands by EXponential Enrichment (SELEX) represents
a state-of-the-art technology to isolate single-stranded (ribo)nucleic acid fragments, named …

Systematic Evolution of Ligands by EXponential Enrichment (SELEX) is a well established
experimental procedure to identify aptamers - synthetic single-stranded (ribo)nucleic …

Oligonucleotide aptamers represent a novel platform for creating ligands with desired
specificity, and they offer many potentially significant advantages over monoclonal antibodies in …

The capability of producing and efficiently processing big data has revolutionized virtually
every field of science and technology and has enabled the analysis of experimental results at …

Aptamers, short RNA or DNA molecules that bind distinct targets with high affinity and specificity,
can be identified using high-throughput systematic evolution of ligands by exponential …

Highly constrained peptides such as the knotted peptide natural products are promising
medicinal agents because of their impressive biostability and potent activity. Yet, libraries of …

With properties such as stability to long-term storage and amenability to repetitive use, nucleic
acid aptamers are compatible with many sensing/transducing platforms intended for use …

Peptide macrocyclization is typically associated with the development of higher affinity and
more protease stable protein ligands, and, as such, is an important tool in peptide drug …

Background Cancer immunotherapy with monoclonal antibodies and chimeric antigen receptor
(CAR) T cell therapies can benefit from selection of new targets with high levels of tumor …