Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The
pathogenesis has for a long time been quite enigmatic, as only very few gene defects were …

Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …

… In the version of this article initially published online, affiliation 30 stating that "These authors
jointly supervised this work" was incorrectly omitted for author Jan J. Molenaar. The error …

Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has
sparked an interest in their epigenetic regulation. Several tumor types include phenotypically …

LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo. …

Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage
neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were …

Kidney tumours are among the most common solid tumours in children, comprising distinct
subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-…

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc
myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of …

Immunotherapy holds great promise for the treatment of pediatric cancers. In neuroblastoma,
the recent implementation of anti-GD2 antibody Dinutuximab into the standard of care has …