Purpose This work describes the production and application of an aerosolised formulation of
chitosan nanoparticles for improved pulmonary siRNA delivery and gene silencing in mice. …

Background Coronary effluent from an isolated perfused heart undergoing ischemic
preconditioning can be transferred to precondition another naïve isolated heart. We investigated the …

Aims Activation of the receptor for advanced glycation end products (RAGE) is associated
with long‐term complications in diabetes mellitus. In this study, we tested whether RAGE …

The multiple convergent evolution of high systemic blood pressure among terrestrial vertebrates
has always been accompanied by lowered pulmonary pressure. In mammals, birds and …

Aims Contact force (CF) between radiofrequency (RF) ablation catheter and myocardium
and ablation index (AI) correlates with RF lesion depth and width in normal-voltage (>1.5 mV) …

Background Sympathetic adrenergic stimulation and the renin-angiotensin-aldosterone
system are highly elevated in right heart failure. We evaluated if treatment with the adrenergic …

Mammals evolved from reptile-like ancestors, and while the mammalian heart is driven by a
distinct sinus node, a sinus node is not apparent in reptiles. We characterized the …

Among lizards, only monitor lizards (Varanidae) have a functionally divided cardiac ventricle.
The division results from the combined function of three partial septa, which may be …

Pulmonary arterial hypertension (PAH) is a fatal disease, and the ultimate cause of death is
right ventricular (RV) failure. In this study, we investigated the acute hemodynamic effects of …

Obesity causes lipid accumulation in the heart and may lead to lipotoxic heart disease.
Traditionally, the size of the cardiac triglyceride pool is thought to reflect the balance between …