Increasing concerns about the rising rates of antibiotic therapy failure and advances in
single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial …

Swarming is the fastest known bacterial mode of surface translocation and enables the
rapid colonization of a nutrient-rich environment and host tissues. This complex multicellular …

Within bacterial populations, a small fraction of persister cells is transiently capable of surviving
exposure to lethal doses of antibiotics. As a bet-hedging strategy, persistence levels are …

Certain infectious diseases caused by pathogenic bacteria are typically chronic in nature.
Potentially deadly examples include tuberculosis, caused by Mycobacterium tuberculosis, …

Bacterial cells can produce and sense signal molecules, allowing the whole population to
initiate a concerted action once a critical concentration (corresponding to a particular …

All bacterial populations harbor a small fraction of transiently antibiotic-tolerant cells called
persisters. These phenotypic variants compromise successful antibiotic treatment because …

A hyperphosphorylated guanosine nucleotide, (p)ppGpp, was initially identified as the effector
molecule responsible for the stringent response in Escherichia coli. However, a rapidly …

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial
infections. Both theory and experiments have suggested that persisters facilitate genetic …

The evolution of antibiotic resistance is a major threat to society and has been predicted to
lead to 10 million casualties annually by 2050 1. Further aggravating the problem, multidrug …

Health care-associated infections present a major threat to modern medical care. Six worrisome
nosocomial pathogens— Enterococcus faecium , Staphylococcus aureus , Klebsiella …