User profiles for Jan Mikelson
 | Jan MikelsonVisiting Reseracher at Makerere University Verified email at mak.ac.ug Cited by 163 |
Optogenetic actuator–ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics
C Dessauges, J Mikelson, M Dobrzyński… - Molecular systems …, 2022 - embopress.org
Combining single‐cell measurements of ERK activity dynamics with perturbations provides
insights into the MAPK network topology. We built circuits consisting of an optogenetic …
insights into the MAPK network topology. We built circuits consisting of an optogenetic …
[HTML][HTML] Likelihood-free nested sampling for parameter inference of biochemical reaction networks
J Mikelson, M Khammash - PLoS computational biology, 2020 - journals.plos.org
The development of mechanistic models of biological systems is a central part of Systems
Biology. One major challenge in developing these models is the accurate inference of model …
Biology. One major challenge in developing these models is the accurate inference of model …
A finite state projection algorithm for the stationary solution of the chemical master equation
The chemical master equation (CME) is frequently used in systems biology to quantify the
effects of stochastic fluctuations that arise due to biomolecular species with low copy numbers. …
effects of stochastic fluctuations that arise due to biomolecular species with low copy numbers. …
Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling
Stimulation of PC ‐12 cells with epidermal ( EGF ) versus nerve ( NGF ) growth factors ( GF s)
biases the distribution between transient and sustained single‐cell ERK activity states, and …
biases the distribution between transient and sustained single‐cell ERK activity states, and …
[HTML][HTML] Parameter inference for stochastic single-cell dynamics from lineage tree data
I Kuzmanovska, A Milias-Argeitis, J Mikelson… - BMC systems …, 2017 - Springer
Background With the advance of experimental techniques such as time-lapse fluorescence
microscopy, the availability of single-cell trajectory data has vastly increased, and so has the …
microscopy, the availability of single-cell trajectory data has vastly increased, and so has the …
[PDF][PDF] Optogenetic actuator/biosensor circuits for large-scale interrogation of ERK dynamics identify sources of MAPK signaling robustness
Measurements of single-cell ERK activity dynamics provide unique insights in the MAPK
network topology. We built genetic circuits consisting of optogenetic actuators activating ERK …
network topology. We built genetic circuits consisting of optogenetic actuators activating ERK …
Cost-effectiveness of pembrolizumab for previously treated MSI-H/dMMR solid tumours in the UK
…, E Brook, K Metcalfe, J Mikelson… - Journal of Medical …, 2024 - Taylor & Francis
Objectives Patients with previously treated microsatellite instability-high (MSI-H)/mismatch
repair deficient (dMMR) tumours have limited chemotherapeutic treatment options. …
repair deficient (dMMR) tumours have limited chemotherapeutic treatment options. …
A parallelizable sampling method for parameter inference of large biochemical reaction models
J Mikelson, M Khammash - arXiv preprint arXiv:1606.08281, 2016 - arxiv.org
The development of mechanistic models of biological systems is a central part of Systems
Biology. One major task in developing these models is the inference of the correct model …
Biology. One major task in developing these models is the inference of the correct model …
[PDF][PDF] Nested Sampling for biochemical reaction networks with applications to ERK signalling: A likelihood-free approach
J Mikelson - 2019 - research-collection.ethz.ch
The development of mechanistic models of biological systems is a central part of systems
biology. The role of these models is to reproduce previously observed biological behaviours …
biology. The role of these models is to reproduce previously observed biological behaviours …
Likelihood-free nested sampling for biochemical reaction networks
J Mikelson, M Khammash - bioRxiv, 2019 - biorxiv.org
The development of mechanistic models of biological systems is a central part of Systems
Biology. One major challenge in developing these models is the accurate inference of the …
Biology. One major challenge in developing these models is the accurate inference of the …