Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the
key regulated step of the Wnt pathway. It is incompletely understood how the Axin1 complex …

Background Pectins are diverse and very complex biomolecules and their structure depends
on the plant species and tissue. It was previously shown that derivatives of pectic polymers …

Immuno-PCR combines specific antibody-based protein detection with the sensitivity of PCR-based
quantification through the use of antibody-DNA conjugates. The production of such …

Environmental stimuli often lead to heterogeneous cellular responses and transcriptional
output. We developed single-cell RNA and Immunodetection (RAID) to allow combined …

Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating
cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-…

Wnt/β-catenin signalling controls development and adult tissue homeostasis and causes
cancer when inappropriately activated. In unstimulated cells, an Axin1-centred multi-protein …

Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by
expression of the OSKM transcription factors. Despite significant effort, relatively little is known …

SCF βTrCP is the ubiquitin ligase for a wide variety of substrates and functions in many
cellular processes. βTrCP, the substrate binding factor of the SCF complex, has two isoforms, …

Cell-based small molecule screening is an effective strategy leading to new medicines.
Scientists in the pharmaceutical industry as well as in academia have made tremendous …

Cell-based small molecule screening is an effective strategy leading to new medicines.
Scientists in the pharmaceutical industry as well as in academia have made tremendous …