The neuronal repressor REST (RE1-silencing transcription factor; also called NRSF) is
expressed at high levels in mouse embryonic stem (ES) cells 1 , but its role in these cells is …

The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be
restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with …

Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse
and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the …

In a transgenic model of ischemic cardiomyopathy in which monocytes are attracted to the
myocardium by the targeted overexpression of monocyte chemoattractant protein-1 (MCP-1), …

To explore the possible role of monocyte chemotactic protein (MCP-1) in inflammatory diseases
of the heart, we expressed the murine MCP-1 (JE) gene under the control of the alpha-…

We examined different weight ranges and hormone dosages to determine superovulation
protocols for 6 mouse strains commonly used in genetic engineering: C57BL/6NHsd, B6(Cg)-…

hnRNP K regulates cellular programs, and changes in its expression and mutational status
have been implicated in neoplastic malignancies. To directly examine its role in …

Background & Aims Chromosomal instability (CIN) is a carcinogenesis event that promotes
metastasis and resistance to therapy by unclear mechanisms. Expression of the colon cancer…

TP53 is commonly altered in human cancer, and Tp53 reactivation suppresses tumours in
vivo in mice 1 , 2 (TP53 and Tp53 are also known as p53). This strategy has proven difficult to …

Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout
mice, providing an alternative to cumbersome and time-consuming traditional embryonic …