Reinforcement learning offers to robotics a framework and set of tools for the design of
sophisticated and hard-to-engineer behaviors. Conversely, the challenges of robotic problems …

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential
functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine …

Many motor skills in humanoid robotics can be learned using parametrized motor primitives
as done in imitation learning. However, most interesting motor learning problems are high-…

Mammalian genomes are spatially organized into compartments, topologically associating
domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. …

Eukaryotic genomes are folded into loops and topologically associating domains, which
contribute to chromatin structure, gene regulation, and gene recombination. These structures …

Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through
the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity—by …

Cohesin complexes mediate sister-chromatid cohesion in dividing cells but may also contribute
to gene regulation in postmitotic cells. How cohesin regulates gene expression is not …

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all
chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an …

Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system.
We have fractionated mitotic Xenopus egg extracts to identify components required for this …

Key events in mitosis such as sister chromatid separation and subsequent inactivation of
cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are …