Background Neurostimulation of the internal globus pallidus has been shown to be effective
in reducing symptoms of primary dystonia. We compared this surgical treatment with sham …

Background Radiotherapy is the standard care in elderly patients with malignant astrocytoma
and the role of primary chemotherapy is poorly defined. We did a randomised trial to …

Background Severe forms of primary dystonia are difficult to manage medically. We assessed
the safety and efficacy of pallidal neurostimulation in patients with primary generalised or …

Background Cervical dystonia is managed mainly by repeated botulinum toxin injections.
We aimed to establish whether pallidal neurostimulation could improve symptoms in patients …

Neuronal oscillations are assumed to play a pivotal role in the pathophysiology of Parkinson's
disease (PD). Neurons in the subthalamic nucleus (STN) generate oscillations which are …

… a,b,c,* ; Meier, Kaare d ; Zaalberg, Paul Brocades e ; Nijhuis, Harold JA f ; Duyvendak,
Wim g ; Vesper, Jan h ; Enggaard, Thomas P. i ; Lenders, Mathieu WPM a,c …

Objectives: Spinal cord stimulation (SCS) for the treatment of chronic pain is a well-established
therapy. However, the requirement that paresthesia be continually felt by the patient has …

Increasing evidence suggests that abnormal oscillatory activity in basal ganglia and cortex
plays a pivotal role in the pathophysiology of Parkinson's disease. Recordings of local field …

Introduction Intrathecal therapy is an important part of the pain treatment algorithm for chronic
disease states. The use of this option is a viable treatment strategy, but it is inherent for …

Background Although subthalamic stimulation is a recognised treatment for motor
complications in Parkinson's disease, reports on behavioural outcomes are controversial, which …