Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Recent progress in the science of aging is driven largely by the use of model systems, ranging
from yeast and nematodes to mice. These models have revealed conservation in genetic …

Loss of genome maintenance may causally contribute to ageing, as exemplified by the
premature appearance of multiple symptoms of ageing in a growing family of human syndromes …

… In this paper, Jan Vijg and colleagues address the vexed question of whether there is a
fundamental limit to human longevity. Their demographic analysis of life expectancy and …

The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

Recent discoveries in the science of ageing indicate that lifespan in model organisms such
as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional …

To study gene mutations in different organs and tissues of an experimental animal, we
produced transgenic mice harboring bacteriophage lambda shuttle vectors integrated in the …

Accumulation of mutations in somatic cells has been implicated as a cause of aging since
the 1950s. However, attempts to establish a causal relationship between somatic mutations …

One of the major impediments in human aging research is the absence of a comprehensive
and actionable set of biomarkers that may be targeted and measured to track the …

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the
accumulation of senescent cells is thought to drive age-related pathology through a …