TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak
in early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …

[HTML][HTML] Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus

J Koch, SJ Schober, SV Hindupur, C Schöning… - Nature …, 2022 - nature.com
CDK4/6 inhibitors (CDK4/6i) and oncolytic viruses are promising therapeutic agents for the
treatment of various cancers. As single agents, CDK4/6 inhibitors that are approved for the …

Advances and highlights in biomarkers of allergic diseases

…, M Huang, M Bel Imam, J Koch… - Allergy, 2021 - Wiley Online Library
During the past years, there has been a global outbreak of allergic diseases, presenting a
considerable medical and socioeconomical burden. A large fraction of allergic diseases is …

[HTML][HTML] Entry of phenuiviruses into mammalian host cells

J Koch, Q Xin, ND Tischler, PY Lozach - Viruses, 2021 - mdpi.com
Phenuiviridae is a large family of arthropod-borne viruses with over 100 species worldwide.
Several cause severe diseases in both humans and livestock. Global warming and the …

Advances and recent developments in asthma in 2020

…, DJ Maurer, D Burla, M Ding, K Jansen, J Koch… - Allergy, 2020 - Wiley Online Library
In this review, we discuss recent publications on asthma and review the studies that have
reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, …

Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling

…, O Staszewski, L Amann, M Gruber, J Koch… - The EMBO …, 2021 - embopress.org
Similar to the brain, the eye is considered an immune‐privileged organ where tissue‐resident
macrophages provide the major immune cell constituents. However, little is known about …

Translation and emerging functions of non‐coding RNAs in inflammation and immunity

E Della Bella, J Koch, K Baerenfaller - Allergy, 2022 - Wiley Online Library
Regulatory non‐coding RNAs (ncRNAs) including small non‐coding RNAs (sRNAs), long
non‐coding RNAs (lncRNAs), and circular RNAs (circRNAs) have gained considerable …

[HTML][HTML] STAT3/5 inhibitors suppress proliferation in bladder cancer and enhance oncolytic adenovirus therapy

SV Hindupur, SC Schmid, JA Koch, A Youssef… - International Journal of …, 2020 - mdpi.com
The JAK-STAT signalling pathway regulates cellular processes like cell division, cell death
and immune regulation. Dysregulation has been identified in solid tumours and STAT3 …

[HTML][HTML] NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice

…, E Nachman, K Richter, C Tamietti, J Koch… - Nature …, 2020 - nature.com
Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to
specific human illnesses such as Alzheimer’s disease. Here we show that the major …

[HTML][HTML] Three dimensional cultivation increases chemo-and radioresistance of colorectal cancer cell lines

J Koch, D Moench, A Maass, C Gromoll, T Hehr… - PLoS …, 2021 - journals.plos.org
Although 2D cell cultures are commonly used to predict therapy response, it has become
clear that 3D cultures may better mimic the in vivo situation and offer the possibility of tailoring …