Developments in microscopy have been instrumental to progress in the life sciences, and
many new techniques have been introduced and led to new discoveries throughout the last …

Cyclic nucleotide-gated (CNG) ion channels mediate sensory signal transduction in
photoreceptors and olfactory cells. Structurally, CNG channels are heterotetramers composed of …

HCN pacemaker channels are tetramers mediating rhythmicity in neuronal and cardiac cells.
The activity of these channels is controlled by both membrane voltage and the ligand cAMP…

Ion channels and transporters are membrane proteins whose functions are driven by
conformational changes. Classical biophysical techniques provide insight into either the structure …

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetrameric
membrane proteins that generate electrical rhythmicity in specialized neurons and …

Plants, as sessile organisms, gained the ability to sense and respond to biotic and abiotic
stressors to survive severe changes in their environments. The change in our climate comes …

Cyclic nucleotide-modulated ion channels are molecular pores that mediate the passage of
ions across the cell membrane in response to cAMP or GMP. Structural insight into this class …

Cyclic nucleotide-sensitive ion channels are molecular pores that open in response to cAMP
or cGMP, which are universal second messengers. Binding of a cyclic nucleotide to the …

Cyclic nucleotide‐gated (CNG) ion channels play a key role in the sensory transduction of
vision and olfaction. The channels are opened by the binding of cyclic nucleotides. Native …

Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels
facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain (CNBD) …