Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet
whether these cells contribute to cognitive deficits and secondary inflammatory pathology …

Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and tissue
morphology to the genome-wide transcriptional profile of cells in an undissociated tissue. …

Reasons for the progressive age-related loss of skeletal muscle mass and function, namely
sarcopenia, are complex. Few studies describe sarcopenia in mice, although this species is …

Exercise has been shown to positively augment adult hippocampal neurogenesis; however,
the cellular and molecular pathways mediating this effect remain largely unknown. Previous …

Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

It is now widely accepted that hippocampal neurogenesis underpins critical cognitive
functions, such as learning and memory. To assess the behavioral importance of adult-born …

Microglia, the resident immune cells of the CNS, have emerged as key regulators of neural
precursor cell activity in the adult brain. However, the microglia-derived factors that mediate …

In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating
factors are proving to be a promising area of research. In this study, we show that the …

Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate
their axons after injury. Neurotrauma to the CNS usually results in axonal damage and …

Studies on the role of the hippocampus in higher cognitive functions such as spatial learning
and memory in rodents are reliant upon robust and objective behavioral tests. This protocol …