Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

…, JL Nourse, T Tran, J Hwe, J Arulmoli… - Proceedings of the …, 2014 - National Acad Sciences
Neural stem cells are multipotent cells with the ability to differentiate into neurons, astrocytes,
and oligodendrocytes. Lineage specification is strongly sensitive to the mechanical …

[HTML][HTML] Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers

…, JR Holt, AC Chang, JL Nourse, J Arulmoli… - Communications …, 2019 - nature.com
Piezo channels transduce mechanical stimuli into electrical and chemical signals to powerfully
influence development, tissue homeostasis, and regeneration. Studies on Piezo1 have …

[HTML][HTML] Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering

J Arulmoli, HJ Wright, DTT Phan, U Sheth, RA Que… - Acta Biomaterialia, 2016 - Elsevier
Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central
nervous system (CNS) trauma since they secrete beneficial trophic factors and differentiate into …

[HTML][HTML] Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner

J Arulmoli, MM Pathak, LP McDonnell, JL Nourse… - Scientific reports, 2015 - nature.com
Neural stem and progenitor cell (NSPC) fate is strongly influenced by mechanotransduction
as modulation of substrate stiffness affects lineage choice. Other types of mechanical stimuli, …

[PDF][PDF] Cell surface N-glycans influence electrophysiological properties and fate potential of neural stem cells

AR Yale, JL Nourse, KR Lee, SN Ahmed, J Arulmoli… - Stem cell reports, 2018 - cell.com
Understanding the cellular properties controlling neural stem and progenitor cell (NSPC)
fate choice will improve their therapeutic potential. The electrophysiological measure whole-…

CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer

HJ Wright, J Arulmoli, M Motazedi, LJ Nelson… - Oncogene, 2016 - nature.com
Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast
cancer that lacks the estrogen, progesterone and HER2 receptors and is resistant to targeted …

Recombinant collagen scaffolds as substrates for human neural stem/progenitor cells

RA Que, J Arulmoli, NA Da Silva… - … Research Part A, 2018 - Wiley Online Library
Adhesion to the microenvironment profoundly affects stem cell functions, including
proliferation and differentiation, and understanding the interaction of stem cells with the …

[HTML][HTML] Increasing label-free stem cell sorting capacity to reach transplantation-scale throughput

MG Simon, Y Li, J Arulmoli, LP McDonnell, A Akil… - …, 2014 - pubs.aip.org
Dielectrophoresis (DEP) has proven an invaluable tool for the enrichment of populations of
stem and progenitor cells owing to its ability to sort cells in a label-free manner and its …

Reflectin as a material for neural stem cell growth

L Phan, R Kautz, J Arulmoli, IH Kim… - … Applied Materials & …, 2016 - ACS Publications
Cephalopods possess remarkable camouflage capabilities, which are enabled by their
complex skin structure and sophisticated nervous system. Such unique characteristics have in …

[PDF][PDF] Myosin-II mediated traction forces evoke localized Piezo1 Ca2+ flickers

KL Ellefsen, A Chang, JL Nourse, JR Holt, J Arulmoli… - Biophysical …, 2019 - cell.com
The human mechanosensitive ion channel PIEZO1 is gated by membrane tension and
regulates essential biological processes such as vascular development and erythrocyte volume …