The majority of research on reactive oxygen species (ROS) has focused on their cellular
toxicities. Stem cells generally have been thought to maintain low levels of ROS as a protection …

A period of mild brain overgrowth with an unknown etiology has been identified as one of
the most common phenotypes in autism. Here, we test the hypothesis that maternal …

The use of stem cells in cell replacement therapy for neurodegenerative diseases has received
a great deal of scientific and public interest in recent years. This is due to the remarkable …

Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence
on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy…

The acute response of the rodent subventricular zone (SVZ) to traumatic brain injury (TBI)
involves a physical expansion through increased cell proliferation. However, the cellular …

Aims: The goal of this study was to determine whether nicotinamide adenine dinucleotide
phosphate (NADPH) oxidase (NOX)-produced reactive oxygen species (ROS) enhance brain …

… To directly compare the properties of mutant (MUT) and WT stem/progenitors, we first examined
the effect of PTEN deficiency on embryonic day (E) 14.5 cortices, an age … Janel Le Belle …

Here we show that conditional deletion of Pten in a subpopulation of adult neural stem cells
in the subependymal zone (SEZ) leads to persistently enhanced neural stem cell self-…

… Janel Le Belle , Janel Le Belle … C and D show high power pictures from the ipsilateral and
contralateral grey matter of the cord from an animal that received a control infusion, while E …

Glioblastoma (GBM) metabolism has traditionally been characterized by a dependence on
aerobic glycolysis, prompting use of the ketogenic diet as a potential therapy. We observed …