User profiles for Janet S. Sinsheimer
Janet SinsheimerProfessor Human Genetics, UCLA Verified email at mednet.ucla.edu Cited by 15138 |
[HTML][HTML] Epigenetic predictor of age
From the moment of conception, we begin to age. A decay of cellular structures, gene regulation,
and DNA sequence ages cells and organisms. DNA methylation patterns change with …
and DNA sequence ages cells and organisms. DNA methylation patterns change with …
Bayesian selection of continuous-time Markov chain evolutionary models
…, RE Weiss, JS Sinsheimer - Molecular biology and …, 2001 - academic.oup.com
We develop a reversible jump Markov chain Monte Carlo approach to estimating the
posterior distribution of phylogenies based on aligned DNA/RNA sequences under several …
posterior distribution of phylogenies based on aligned DNA/RNA sequences under several …
[PDF][PDF] Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most disorders, …
disease gene discovery. A substantial number of recent GWAS indicate that for most disorders, …
Normal/independent distributions and their applications in robust regression
K Lange, JS Sinsheimer - Journal of Computational and Graphical …, 1993 - Taylor & Francis
Maximum likelihood estimation with nonnormal error distributions provides one method of
robust regression. Certain families of normal/independent distributions are particularly …
robust regression. Certain families of normal/independent distributions are particularly …
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
P Pajukanta, HE Lilja, JS Sinsheimer, RM Cantor… - Nature …, 2004 - nature.com
Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both 1 , 2 , is observed in about 20% of individuals with premature …
cholesterol, triglycerides or both 1 , 2 , is observed in about 20% of individuals with premature …
Chromosome 1 loci in Finnish schizophrenia families
…, P Ellonen, G Chan, JS Sinsheimer… - Human molecular …, 2001 - academic.oup.com
We have earlier reported evidence for linkage to two regions on chromosome 1q32–q42 in
schizophrenia families collected for two separate studies in Finland. Here we report the …
schizophrenia families collected for two separate studies in Finland. Here we report the …
[PDF][PDF] A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27
…, E Kempas, T Ylisaukko-Oja, JS Sinsheimer… - The American Journal of …, 2002 - cell.com
To identify genetic loci for autism-spectrum disorders, we have performed a two-stage
genomewide scan in 38 Finnish families. The detailed clinical examination of all family members …
genomewide scan in 38 Finnish families. The detailed clinical examination of all family members …
Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs
…, CDL Wynne, EA Ostrander, JS Sinsheimer… - Science …, 2017 - science.org
Although considerable progress has been made in understanding the genetic basis of
morphologic traits (for example, body size and coat color) in dogs and wolves, the genetic basis of …
morphologic traits (for example, body size and coat color) in dogs and wolves, the genetic basis of …
[PDF][PDF] MARRVEL: integration of human and model organism genetic resources to facilitate functional annotation of the human genome
One major challenge encountered with interpreting human genetic variants is the limited
understanding of the functional impact of genetic alterations on biological processes. …
understanding of the functional impact of genetic alterations on biological processes. …
[HTML][HTML] Association screening of common and rare genetic variants by penalized regression
Motivation: This article extends our recent research on penalized estimation methods in
genome-wide association studies to the realm of rare variants. Results: The new strategy is …
genome-wide association studies to the realm of rare variants. Results: The new strategy is …