As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop new …

Background The discovery of malaria transmission-blocking compounds is seen as key to
malaria elimination strategies and gametocyte-screening platforms are critical filters to identify …

Histone posttranslational modifications (PTMs) frequently co-occur on the same chromatin
domains or even in the same molecule. It is now established that these "histone codes" are …

The continued emergence of resistance to front-line antimalarial treatments is of great concern.
Therefore, new compounds that potentially have a novel target in various developmental …

The epigenome of the malaria parasite, Plasmodium falciparum, is associated with regulation
of various essential processes in the parasite including control of proliferation during …

Plasmodium parasites have a complex life cycle that includes development in the human host
as well as the Anopheles vector. Successful transmission of the parasite between its host …

Chemical matter is needed to target the divergent biology associated with the different life
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines …

Background Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite
to be transmitted between the infected human and the mosquito host but the molecular …

Compounds acting on multiple targets are critical to combating antimalarial drug resistance.
Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor …

The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodium
phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In …