Introduction We compared levels of protein and mRNA expression of three members of the
claudin (CLDN) family in malignant breast tumours and benign lesions. Methods Altogether, …

Several studies using genome-wide molecular techniques have reported various degrees
of genetic heterogeneity between primary tumours and their distant metastases. However, it …

Background: A high percentage of stroma predicts poor survival in triple-negative breast
cancers but is diminished in studies of unselected cases. We determined the prognostic …

The aim of our retrospective study was to analyze patterns of subtype specific metastatic
spread and to identify the time course of distant metastases. A consecutive series of 490 …

Background Studies have partly demonstrated the clinical validity of Ki-67 as a predictive
marker in the neoadjuvant setting, but the question of the best cut-off points as well as the …

Background and Aims Connexins and their cell membrane channels contribute to the control
of cell proliferation and compartmental functions in breast glands and their deregulation is …

Papillary lesions of the breast represent a heterogeneous group of lesions including benign
papillomas, papillomas with focal epithelial atypia, fully fledged ductal carcinoma in situ (…

The Ki67 labelling index (LI – proportion of staining cells) is widely used to reflect proliferation
in breast carcinomas. Several cut-off values have been suggested to distinguish between …

Claudins (CLDN) are tight junction proteins which contribute to the paracellular transport
and ionic permeability of various epithelia. In recent years they came into focus for their …

Pregnancy Associated Breast Cancer (PABC) manifests during pregnancy or within a year
following delivery. We sought to investigate differences in management, outcome, clinical, …