User profiles for Japinder Nijjer

Japinder Nijjer

Senior Scientist, AstraZeneca
Verified email at yale.edu
Cited by 279

Morphogenesis and cell ordering in confined bacterial biofilms

Q Zhang, J Li, J Nijjer, H Lu, M Kothari… - Proceedings of the …, 2021 - National Acad Sciences
Biofilms are aggregates of bacterial cells surrounded by an extracellular matrix. Much progress
has been made in studying biofilm growth on solid substrates; however, little is known …

The dynamics of miscible viscous fingering from onset to shutdown

JS Nijjer, DR Hewitt, JA Neufeld - Journal of Fluid Mechanics, 2018 - cambridge.org
We examine the full ‘life cycle’ of miscible viscous fingering from onset to shutdown with the
aid of high-resolution numerical simulations. We study the injection of one fluid into a planar …

Stable and unstable miscible displacements in layered porous media

JS Nijjer, DR Hewitt, JA Neufeld - Journal of Fluid Mechanics, 2019 - cambridge.org
The effect of permeability heterogeneities and viscosity variations on miscible displacement
processes in porous media is examined using high-resolution numerical simulations and …

Bacteria surfing the elastic wave

J Nijjer, T Cohen, J Yan - Nature Physics, 2023 - nature.com
Elasticity-driven synchronization in active solids has been predicted theoretically and was
recently realized in a synthetic system. A biological realization is now demonstrated in a …

[HTML][HTML] Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization

…, Z Jiang, RF Lee, L Wu, C Chak, J Nijjer… - Nature …, 2023 - nature.com
Bacterial biofilms are formed on environmental surfaces and host tissues, and facilitate host
colonization and antibiotic resistance by human pathogens. Bacteria often express multiple …

[HTML][HTML] Mechanical forces drive a reorientation cascade leading to biofilm self-patterning

J Nijjer, C Li, Q Zhang, H Lu, S Zhang, J Yan - Nature communications, 2021 - nature.com
In growing active matter systems, a large collection of engineered or living autonomous units
metabolize free energy and create order at different length scales as they proliferate and …

Biofilms as self-shaping growing nematics

J Nijjer, C Li, M Kothari, T Henzel, Q Zhang, JSB Tai… - Nature Physics, 2023 - nature.com
Active nematics are the non-equilibrium analogue of passive liquid crystals. They consist of
anisotropic units that consume free energy to drive emergent behaviour. As with liquid crystal …

Flow-induced compaction of a deformable porous medium

DR Hewitt, JS Nijjer, MG Worster, JA Neufeld - Physical Review E, 2016 - APS
Fluid flowing through a deformable porous medium imparts viscous drag on the solid matrix,
causing it to deform. This effect is investigated theoretically and experimentally in a one-…

Mechanical resilience of biofilms toward environmental perturbations mediated by extracellular matrix

…, D Nguyen, JSB Tai, XJ Xu, J Nijjer… - Advanced Functional …, 2022 - Wiley Online Library
Biofilms are surface‐associated communities of bacterial cells embedded in an extracellular
matrix (ECM). Biofilm cells can survive and thrive in various dynamic environments causing …

[HTML][HTML] Lipoarabinomannan mediates localized cell wall integrity during division in mycobacteria

IL Sparks, T Kado, M Prithviraj, J Nijjer, J Yan… - Nature …, 2024 - nature.com
The growth and division of mycobacteria, which include clinically relevant pathogens,
deviate from that of canonical bacterial models. Despite their Gram-positive ancestry, …