Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an
aggressive clinical course, whereas others having an indolent behavior. We conducted an …

Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose
pathogenesis is not fully understood. The neural transcription factor SOX11 is overexpressed in …

SOX11 is overexpressed in several solid tumors and in the vast majority of aggressive mantle
cell lymphomas (MCLs). We have recently proven that SOX11 silencing reduces tumor …

Retroviral gene transfer of interleukin-12 (IL-12) into T cells markedly enhances antitumor
efficacy upon adoptive transfer but has clinically shown unacceptable severe side effects. To …

SOX11 overexpression in mantle cell lymphoma (MCL) has been associated with more
aggressive behavior and worse outcome. However, SOX11 oncogenic pathways driving MCL …

Background Despite the growing interest in immunotherapeutic interventions for endometrial
cancer (EC), the prevalence, phenotype, specificity and prognostic value of tumor …

The diagnosis of mantle cell lymphoma (MCL) can be difficult, especially when no t (11; 14)
translocation and cyclin D1 overexpression can be detected. In such cases, the transcription …

Monocytes/macrophages (MΦs), osteoclasts (OCs), and dendritic cells (DCs) are closely
related cell types of high clinical significance, but the exact steps in their lineage commitment …

Purpose: Tumor antigens are central to antitumor immunity. Recent evidence suggests that
peptides from noncanonical (nonC) aberrantly translated proteins can be presented on HLA-I …

Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell
neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we …