Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies include …

Small laboratory cage trials of non-drive and gene-drive strains of the Asian malaria vector
mosquito, Anopheles stephensi, were used to investigate release ratios and other strain …

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow
fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. …

A recurring target-site mutation identified in various pests and disease vectors alters the
voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to …

CRISPR-Cas9-based gene drive systems possess the inherent capacity to spread progressively
throughout target populations. Here we describe two self-copying (or active) guide RNA-…

CRISPR-based gene drives can spread through wild populations by biasing their own
transmission above the 50% value predicted by Mendelian inheritance. These technologies offer …

Malaria, dengue, Zika and other mosquito‐borne diseases continue to pose a major global
health burden through much of the world, despite the widespread distribution of insecticide‐…

Interest in gene drive technology has continued to grow as promising new drive systems have
been developed in the lab and discussions are moving towards implementing field trials. …

Homing-based gene drives, engineered using CRISPR/Cas9, have been proposed to
spread desirable genes throughout populations. However, invasion of such drives can be …