To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

CodY, a global regulator of gene expression in low G + C Gram‐positive bacteria, was
found to repress toxin gene expression in Clostridium difficile. Inactivation of the codY gene …

RecA is important in recombination, DNA repair and repair of replication forks. It functions
through the production of a protein–DNA filament. To study the localization of RecA in live …

As development unfolds, DNA replication is not only coordinated with cell proliferation, but
is regulated uniquely in specific cell types and organs. This differential regulation of DNA …

Precise DNA replication is crucial for genome maintenance, yet this process has been inherently
difficult to study on a genome-wide level in untransformed differentiated metazoan cells…

Polyploid or polytene cells, which have more than 2C DNA content, are widespread
throughout nature and present in most differentiated Drosophila tissues. These cells also can …

Histone modifications are critical for regulating chromatin structure and gene expression.
Dysregulation of histone modifications likely contributes to disease states and cancer. …

10.7554/eLife.39140.001 Control of DNA copy number is essential to maintain genome
stability and ensure proper cell and tissue function. In Drosophila polyploid cells, the SNF2-…

Successful duplication of the genome requires the accurate replication of billions of base
pairs of DNA within a relatively short time frame. Failure to accurately replicate the genome …

The origin recognition complex (ORC) binds throughout the genome to initiate DNA replication.
In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase …