User profiles for Jared R. Auclair
 | Jared AuclairInterim Dean, Vice Provost Research Economic Development and Director Bioinnovation Verified email at northeastern.edu Cited by 1449 |
A soluble α-synuclein construct forms a dynamic tetramer
…, LTT Nguyen, J Liao, JR Auclair… - Proceedings of the …, 2011 - National Acad Sciences
A heterologously expressed form of the human Parkinson disease-associated protein α-synuclein
with a 10-residue N-terminal extension is shown to form a stable tetramer in the …
with a 10-residue N-terminal extension is shown to form a stable tetramer in the …
[HTML][HTML] Best practices and benchmarks for intact protein analysis for top-down mass spectrometry
…, A Koller, JJ Wolff, IDG Campuzano, JR Auclair… - Nature …, 2019 - nature.com
One gene can give rise to many functionally distinct proteoforms, each of which has a
characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins …
characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins …
Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis
JR Auclair, KJ Boggio, GA Petsko… - Proceedings of the …, 2010 - National Acad Sciences
Amyotrophic lateral sclerosis (ALS) is a disorder characterized by the death of both upper
and lower motor neurons and by 3- to 5-yr median survival postdiagnosis. The only US Food …
and lower motor neurons and by 3- to 5-yr median survival postdiagnosis. The only US Food …
Early introduction and rise of the Omicron SARS-CoV-2 variant in highly vaccinated university populations
…, JT Platt, KR Jacobson, T Bouton, S Yune, JR Auclair… - medRxiv, 2022 - medrxiv.org
The Omicron variant of SARS-CoV-2 is transmissible in vaccinated and unvaccinated
populations. Here, we describe the rapid dominance of Omicron following its introduction to three …
populations. Here, we describe the rapid dominance of Omicron following its introduction to three …
Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5
Common yet often overlooked, deamidation of peptidyl asparagine (Asn or N) generates
aspartic acid (Asp or D) or isoaspartic acid (isoAsp or isoD). Being a spontaneous, non-…
aspartic acid (Asp or D) or isoaspartic acid (isoAsp or isoD). Being a spontaneous, non-…
Early introduction and rise of the Omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant in highly vaccinated university populations
…, T Bouton, S Yune, JR Auclair… - Clinical Infectious …, 2023 - academic.oup.com
Background The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
is highly transmissible in vaccinated and unvaccinated populations. The dynamics …
is highly transmissible in vaccinated and unvaccinated populations. The dynamics …
Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage
JR Auclair, JL Johnson, Q Liu, JP Salisbury… - Biochemistry, 2013 - ACS Publications
Reactive oxygen species (ROS) are cytotoxic. To remove ROS, cells have developed ROS-specific
defense mechanisms, including the enzyme Cu/Zn superoxide dismutase (SOD1), …
defense mechanisms, including the enzyme Cu/Zn superoxide dismutase (SOD1), …
[HTML][HTML] A novel rolling circle amplification-based detection of SARS-CoV-2 with multi-region padlock hybridization
…, H Robin, VV Demidov, GS Ugolini, JR Auclair… - Diagnostics, 2022 - mdpi.com
SARS-CoV-2 has remained a global health burden, primarily due to the continuous evolution
of different mutant strains. These mutations present challenges to the detection of the virus, …
of different mutant strains. These mutations present challenges to the detection of the virus, …
Cyclic thiosulfinates and cyclic disulfides selectively cross-link thiols while avoiding modification of lone thiols
This work addresses the need for chemical tools that can selectively form cross-links.
Contemporary thiol-selective cross-linkers, for example, modify all accessible thiols, but only form …
Contemporary thiol-selective cross-linkers, for example, modify all accessible thiols, but only form …
[HTML][HTML] Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis
MS Rotunno, JR Auclair, S Maniatis, SA Shaffer… - Journal of Biological …, 2014 - ASBMB
Mutations and aberrant post-translational modifications within Cu,Zn-superoxide dismutase (SOD1)
cause this otherwise protective enzyme to misfold, leading to amyotrophic lateral …
cause this otherwise protective enzyme to misfold, leading to amyotrophic lateral …