Widespread adoption of massively parallel deoxyribonucleic acid (DNA) sequencing
instruments has prompted the recent development of de novo short read assembly algorithms. A …

We report the sequencing and assembly of a reference genome for the human GM12878
Utah/Ceph cell line using the MinION (Oxford Nanopore Technologies) nanopore sequencer. …

The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over
28,599 cases and more than 11,299 deaths 1 . Genome sequencing in viral outbreaks is …

Diverse microbial communities of bacteria, archaea, viruses and single-celled eukaryotes
have crucial roles in the environment and in human health. However, microbes are frequently …

We have assembled de novo the Escherichia coli K-12 MG1655 chromosome in a single 4.6-Mb
contig using only nanopore data. Our method has three stages: (i) overlaps are …

Genome sequencing has become a powerful tool for studying emerging infectious diseases;
however, genome sequencing directly from clinical samples (ie, without isolation and culture…

Multiple somatic rearrangements are often found in cancer genomes; however, the underlying
processes of rearrangement and their contribution to cancer development are poorly …

De novo genome sequence assembly is important both to generate new sequence
assemblies for previously uncharacterized genomes and to identify the genome sequence of …

The human reference genome assembly plays a central role in nearly all aspects of today's
basic and clinical research. GRCh38 is the first coordinate-changing assembly update since …

Gorillas are humans’ closest living relatives after chimpanzees, and are of comparable
importance for the study of human origins and evolution. Here we present the assembly and …