User profiles for Jari Häkkinen
 | Jari HäkkinenDepartment of Oncology and Pathology, Clinical Sciences, Lund University, Sweden Verified email at med.lu.se Cited by 3039 |
[HTML][HTML] GOBO: gene expression-based outcome for breast cancer online
Microarray-based gene expression analysis holds promise of improving prognostication and
treatment decisions for breast cancer patients. However, the heterogeneity of breast cancer …
treatment decisions for breast cancer patients. However, the heterogeneity of breast cancer …
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study
…, J Vallon-Christersson, C Reuterswärd, J Häkkinen… - Nature medicine, 2019 - nature.com
Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome
interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast …
interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast …
[HTML][HTML] The Sweden Cancerome Analysis Network-Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer …
Background Breast cancer exhibits significant molecular, pathological, and clinical
heterogeneity. Current clinicopathological evaluation is imperfect for predicting outcome, which …
heterogeneity. Current clinicopathological evaluation is imperfect for predicting outcome, which …
[HTML][HTML] Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic
…, J Vallon-Christersson, C Hegardt, J Häkkinen… - Annals of …, 2016 - Elsevier
Background A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either
germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the …
germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the …
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
…, E Cordero, BK Haller, J Häkkinen… - Nature medicine, 2018 - nature.com
Breast tumors of the basal-like, hormone receptor–negative subtype remain an unmet
clinical challenge, as there is high rate of recurrence and poor survival in patients following …
clinical challenge, as there is high rate of recurrence and poor survival in patients following …
Clinical value of RNA sequencing–based classifiers for prediction of the five conventional breast cancer biomarkers: a report from the population-based multicenter …
…, D Grabau, A Ehinger, J Häkkinen… - JCO Precision …, 2018 - ascopubs.org
Purpose In early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER),
progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and …
progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and …
Colour interference and confinement effects in W-pair production
G Gustafson, J Häkkinen - Zeitschrift für Physik C Particles and Fields, 1994 - Springer
… G6sta Gustafson, Jari H/ikkinen Department of Theoretical Physics, S61vegatan 14A, S-223
62 Lund, Sweden, (e-mail: gosta@thep.lu.se; jari@thep.lu.se) …
62 Lund, Sweden, (e-mail: gosta@thep.lu.se; jari@thep.lu.se) …
[HTML][HTML] Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
…, S Mitra, E Niméus, K Holm, J Häkkinen… - Nature …, 2020 - nature.com
Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient
breast tumors caused by genetic or epigenetic alterations in key pathway genes. We …
breast tumors caused by genetic or epigenetic alterations in key pathway genes. We …
The proteios software environment: an extensible multiuser platform for management and analysis of proteomics data
J Hakkinen, G Vincic, O Månsson… - Journal of proteome …, 2009 - ACS Publications
Proteome analysis involves many steps that generate large quantities of data in different
formats. This creates a need for automatic data merging and extraction of important features …
formats. This creates a need for automatic data merging and extraction of important features …
[PDF][PDF] The X-linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma
…, E Cordero, A Bosch, F Rosengren, J Häkkinen… - Cell reports, 2019 - cell.com
The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently
altered in various human cancers, including melanomas. Despite its important roles in …
altered in various human cancers, including melanomas. Despite its important roles in …