[HTML][HTML] Structural basis for potency differences between GDF8 and GDF11
Background Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members
of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a …
of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a …
Structural perspective of BMP ligands and signaling
…, KN Hart, EC Kappes, C Kattamuri, JC McCoy… - Bone, 2020 - Elsevier
The Bone Morphogenetic Proteins (BMPs) are the largest class signaling molecules within
the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a wide …
the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a wide …
Structure of the human myostatin precursor and determinants of growth factor latency
TR Cotton, G Fischer, X Wang, JC McCoy… - The EMBO …, 2018 - embopress.org
Myostatin, a key regulator of muscle mass in vertebrates, is biosynthesised as a latent
precursor in muscle and is activated by sequential proteolysis of the pro‐domain. To investigate …
precursor in muscle and is activated by sequential proteolysis of the pro‐domain. To investigate …
Molecular characterization of latent GDF8 reveals mechanisms of activation
RG Walker, JC McCoy, M Czepnik… - Proceedings of the …, 2018 - National Acad Sciences
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. …
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. …
Structural biology of the TGFβ family
EJ Goebel, KN Hart, JC McCoy… - … Biology and Medicine, 2019 - journals.sagepub.com
The transforming growth factor beta (TGFβ) signaling pathway orchestrates a wide breadth
of biological processes, ranging from bone development to reproduction. Given this, there …
of biological processes, ranging from bone development to reproduction. Given this, there …
Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans
Cleft lip with or without cleft palate (CL/P) is generally viewed as a complex trait with multiple
genetic and environmental contributions. In 70% of cases, CL/P presents as an isolated …
genetic and environmental contributions. In 70% of cases, CL/P presents as an isolated …
[HTML][HTML] Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11
Growth differentiation factor 8 (GDF8; also known as myostatin) and GDF11 are closely
related members of the transforming growth factor β (TGF-β) family. GDF8 strongly and …
related members of the transforming growth factor β (TGF-β) family. GDF8 strongly and …
Characterization of tolloid-mediated cleavage of the GDF8 procomplex
JC McCoy, EJ Goebel, TB Thompson - Biochemical Journal, 2021 - portlandpress.com
Growth differentiation factor 8 (GDF8), aka myostatin, is a member of the larger TGFβ
superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator of …
superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator of …
Baculovirus FP25K localization: role of the coiled-coil domain
TA Garretson, JC McCoy, XW Cheng - Journal of Virology, 2016 - Am Soc Microbiol
Two types of viruses are produced during the baculovirus life cycle: budded virus (BV) and
occlusion-derived virus (ODV). A particular baculovirus protein, FP25K, is involved in the …
occlusion-derived virus (ODV). A particular baculovirus protein, FP25K, is involved in the …
Molecular characterization of latent GDF8 reveals mechanisms of activation
Growth/differentiation factor 8 (GDF8) or myostatin negatively regulates of muscle mass. GDF8
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-…
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-…