[HTML][HTML] Structural basis for potency differences between GDF8 and GDF11

RG Walker, M Czepnik, EJ Goebel, JC McCoy, A Vujic… - BMC biology, 2017 - Springer
Background Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members
of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a …

Structural perspective of BMP ligands and signaling

…, KN Hart, EC Kappes, C Kattamuri, JC McCoy… - Bone, 2020 - Elsevier
The Bone Morphogenetic Proteins (BMPs) are the largest class signaling molecules within
the greater Transforming Growth Factor Beta (TGFβ) family, and are responsible for a wide …

Structure of the human myostatin precursor and determinants of growth factor latency

TR Cotton, G Fischer, X Wang, JC McCoy… - The EMBO …, 2018 - embopress.org
Myostatin, a key regulator of muscle mass in vertebrates, is biosynthesised as a latent
precursor in muscle and is activated by sequential proteolysis of the pro‐domain. To investigate …

Molecular characterization of latent GDF8 reveals mechanisms of activation

RG Walker, JC McCoy, M Czepnik… - Proceedings of the …, 2018 - National Acad Sciences
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. …

Structural biology of the TGFβ family

EJ Goebel, KN Hart, JC McCoy… - … Biology and Medicine, 2019 - journals.sagepub.com
The transforming growth factor beta (TGFβ) signaling pathway orchestrates a wide breadth
of biological processes, ranging from bone development to reproduction. Given this, there …

Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans

TC Cox, AC Lidral, JC McCoy, H Liu, LL Cox… - Human …, 2019 - Wiley Online Library
Cleft lip with or without cleft palate (CL/P) is generally viewed as a complex trait with multiple
genetic and environmental contributions. In 70% of cases, CL/P presents as an isolated …

[HTML][HTML] Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11

JC McCoy, RG Walker, NH Murray… - Journal of Biological …, 2019 - ASBMB
Growth differentiation factor 8 (GDF8; also known as myostatin) and GDF11 are closely
related members of the transforming growth factor β (TGF-β) family. GDF8 strongly and …

Characterization of tolloid-mediated cleavage of the GDF8 procomplex

JC McCoy, EJ Goebel, TB Thompson - Biochemical Journal, 2021 - portlandpress.com
Growth differentiation factor 8 (GDF8), aka myostatin, is a member of the larger TGFβ
superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator of …

Baculovirus FP25K localization: role of the coiled-coil domain

TA Garretson, JC McCoy, XW Cheng - Journal of Virology, 2016 - Am Soc Microbiol
Two types of viruses are produced during the baculovirus life cycle: budded virus (BV) and
occlusion-derived virus (ODV). A particular baculovirus protein, FP25K, is involved in the …

Molecular characterization of latent GDF8 reveals mechanisms of activation

RG Walker, JC McCoy, M Czepnik, MJ Mills, A Hagg… - BioRxiv, 2017 - biorxiv.org
Growth/differentiation factor 8 (GDF8) or myostatin negatively regulates of muscle mass. GDF8
is held in a latent state through interactions with its N-terminal prodomain, much like TGF-…