PksA, which initiates biosynthesis of the environmental carcinogen aflatoxin B1, is one of
the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood family of …

Genomics and metabolomics are widely used to explore specialized metabolite diversity.
The Paired Omics Data Platform is a community initiative to systematically document links …

Bacteria belonging to the genera Photorhabdus and Xenorhabdus participate in a trilateral
symbiosis in which they enable their nematode hosts to parasitize insect larvae [1]. The …

Fungal aromatic polyketides constitute a large family of bioactive natural products and are
synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their diverse …

Hydrophobic uncharged drugs such as docetaxel are difficult to encapsulate and retain in
liposomal nanoparticles (LNP). In this work we show that a weak base derivative of docetaxel …

The majority of bacterial species do not grow on synthetic media. Many non-growers require
growth factors from other bacteria, but the nature of these compounds is largely unknown. …

Microbiota-derived metabolites that elicit DNA damage can contribute to colorectal cancer (CRC).
However, the full spectrum of genotoxic chemicals produced by indigenous gut …

The intestinal microbiota produces tens of thousands of metabolites. Here, we used host
sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate …

Members of the human microbiota are increasingly being correlated to human health and
disease states, but the majority of the underlying microbial metabolites that regulate host–…

Polyketides are a class of natural products with diverse structures and biological activities.
The structural variability of aromatic products of fungal nonreducing, multidomain iterative …