Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic
function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)…

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor
that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association …

Elevated risk of developing Alzheimer's disease (AD) is associated with hypomorphic variants
of TREM2, a surface receptor required for microglial responses to neurodegeneration, …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Glia have been implicated in Alzheimer’s disease (AD) pathogenesis. Variants of the microglia
receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that
recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) …

Tau-mediated neurodegeneration is a hallmark of Alzheimer’s disease. Primary tauopathies
are characterized by pathological tau accumulation and neuronal and synaptic loss. …

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease
and directly influences tauopathy and tau-mediated neurodegeneration. ApoE4 has strong …

Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2)
were recently found to increase the risk for developing Alzheimer’s disease (AD). In the …

Background Recent genome-wide association studies linked variants in TREM2 to a strong
increase in the odds of developing Alzheimer’s disease. The mechanism by which TREM2 …