The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in
vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral …

Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by expansion
of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. …

The ability of an RNA virus to exist as a population of genetically distinct variants permits the
virus to overcome events during infections that would otherwise limit virus multiplication or …

Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30
year history, the mechanism of action of this compound remains unclear and somewhat …

The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for
therapeutics that inhibit the SARS−COV-2 virus and suppress the fulminant inflammation …

PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen
and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, …

RNA viruses exhibit increased mutation frequencies relative to other organisms. Recent
work has attempted to exploit this unique feature by increasing the viral mutation frequency …

The ability to extinguish a viral population of fixed reproductive capacity by causing small
changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of …

RNA viruses exhibit extraordinarily high mutation rates during genome replication.
Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as …

As part of our studies of lethal viral mutagens, a series of 5-substituted cytidine analogues
were synthesized and evaluated for antiviral activity. Among the compounds examined, 5-…