Prevalence, characteristics, and outcomes of COVID-19–associated acute myocarditis
Background: Acute myocarditis (AM) is thought to be a rare cardiovascular complication of
COVID-19, although minimal data are available beyond case reports. We aim to report the …
COVID-19, although minimal data are available beyond case reports. We aim to report the …
[HTML][HTML] Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
…, BP Woodall, LJ Leon, E Zumaya, J Duran… - Nature …, 2023 - nature.com
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms
JM Duran, CA Makarewich, TE Sharp… - Circulation …, 2013 - Am Heart Assoc
Rationale: Autologous bone marrow–derived or cardiac-derived stem cell therapy for heart
disease has demonstrated safety and efficacy in clinical trials, but functional improvements …
disease has demonstrated safety and efficacy in clinical trials, but functional improvements …
Increased peripheral blood neutrophil activation phenotypes and neutrophil extracellular trap formation in critically ill coronavirus disease 2019 (COVID-19) patients: a …
…, V Pretorius, A Malhotra, X Sun, J Duran… - Clinical Infectious …, 2022 - academic.oup.com
Background Increased inflammation has been well defined in coronavirus disease 2019 (COVID-19),
while definitive pathways driving severe forms of this disease remain uncertain. …
while definitive pathways driving severe forms of this disease remain uncertain. …
Natriuretic peptides in heart failure: atrial and B-type natriuretic peptides
AS Maisel, JM Duran, N Wettersten - Heart failure clinics, 2018 - heartfailure.theclinics.com
The natriuretic peptides (NPs) play a critical role in maintaining homeostasis in the cardiovascular
system, serving as counter-regulatory hormones for volume and pressure overload. It …
system, serving as counter-regulatory hormones for volume and pressure overload. It …
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
…, A Claire, V Castillo, M Hernandez, H Russo, J Duran… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …
in the lungs in the setting of an overzealous immune response whose origin remains …
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction
…, CA Makarewich, H Kubo, W Wang, JM Duran… - Circulation …, 2012 - Am Heart Assoc
Rationale: Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to
cardiac arrhythmias and heart failure (HF) after myocardial infarction (MI). It has been …
cardiac arrhythmias and heart failure (HF) after myocardial infarction (MI). It has been …
Acute catecholamine exposure causes reversible myocyte injury without cardiac regeneration
M Wallner, JM Duran, S Mohsin, CD Troupes… - Circulation …, 2016 - Am Heart Assoc
Rationale: Catecholamines increase cardiac contractility, but exposure to high concentrations
or prolonged exposures can cause cardiac injury. A recent study demonstrated that a …
or prolonged exposures can cause cardiac injury. A recent study demonstrated that a …
Sorafenib cardiotoxicity increases mortality after myocardial infarction
JM Duran, CA Makarewich, D Trappanese… - Circulation …, 2014 - Am Heart Assoc
Rationale: Sorafenib is an effective treatment for renal cell carcinoma, but recent clinical
reports have documented its cardiotoxicity through an unknown mechanism. Objective: …
reports have documented its cardiotoxicity through an unknown mechanism. Objective: …
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity
…, SL Leibel, AF Garretson, AE Clark, JM Duran… - Science …, 2021 - science.org
Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric patients
typically experiencing less severe infection than adults and especially the elderly. The …
typically experiencing less severe infection than adults and especially the elderly. The …