The development of new antibiotics to treat infections caused by drug-resistant Gram-negative
pathogens is of paramount importance as antibiotic resistance continues to increase …

There has been a significant reduction in annual tuberculosis incidence since the World
Health Organization declared tuberculosis a global health threat. However, treatment of M. …

Determining the molecular basis for target selectivity is of particular importance in drug
discovery. The ideal antibiotic should be active against a broad spectrum of pathogenic …

Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics
in preclinical/clinical development. We previously reported dioxane-linked NBTIs with …

Toxin‐antitoxin loci regulate adaptive responses to stresses associated with the host
environment and drug exposure. Phylogenomic studies have shown that Mycobacterium …

Francisella tularensis is a highly virulent pathogenic bacterium. In order to identify novel
potential antibacterial agents against F. tularensis, libraries of trisubstituted benzimidazoles …

Paneth cells secrete microbicidal enteric α-defensins into the small intestinal lumen, and
cryptdin-4 (Crp4) is the most bactericidal of the mouse α-defensin peptides in vitro. Here, site-…

We show that cryptdin-4 (Crp4), an antimicrobial peptide found in mice, induces the aggregation
and hemi-fusion of charged phospholipid vesicles constructed of the anionic lipid POPG …

β-Ketoacyl-ACP synthases (KAS) are key enzymes involved in the type II bacterial fatty acid
biosynthesis (FASII) pathway and are putative targets for antibacterial discovery. Several …

Despite significant research efforts, treatment options for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) remain limited. This is due in part to a lack of therapeutics that …