User profiles for Jason Ernst
Jason ErnstProfessor, University of California, Los Angeles Verified email at ucla.edu Cited by 44765 |
ChromHMM: automating chromatin-state discovery and characterization
Chromatin-state annotation using combinations of chromatin modification patterns has
emerged as a powerful approach for discovering regulatory regions and their cell type–specific …
emerged as a powerful approach for discovering regulatory regions and their cell type–specific …
Mapping and analysis of chromatin state dynamics in nine human cell types
Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non-…
of regulatory activity. The approach is especially well suited to the characterization of non-…
Chromatin-state discovery and genome annotation with ChromHMM
Noncoding DNA regions have central roles in human biology, evolution, and disease.
ChromHMM helps to annotate the noncoding genome using epigenomic information across one …
ChromHMM helps to annotate the noncoding genome using epigenomic information across one …
[HTML][HTML] Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …
its association with human disease, but epigenomic studies lack a similar reference. To …
[HTML][HTML] STEM: a tool for the analysis of short time series gene expression data
J Ernst, Z Bar-Joseph - BMC bioinformatics, 2006 - Springer
Background Time series microarray experiments are widely used to study dynamical biological
processes. Due to the cost of microarray experiments, and also in some cases the limited …
processes. Due to the cost of microarray experiments, and also in some cases the limited …
Discovery and characterization of chromatin states for systematic annotation of the human genome
A plethora of epigenetic modifications have been described in the human genome and shown
to play diverse roles in gene regulation, cellular differentiation and the onset of disease. …
to play diverse roles in gene regulation, cellular differentiation and the onset of disease. …
[HTML][HTML] A high-resolution map of human evolutionary constraint using 29 mammals
The comparison of related genomes has emerged as a powerful lens for genome interpretation.
Here we report the sequencing and comparative analysis of 29 eutherian genomes. We …
Here we report the sequencing and comparative analysis of 29 eutherian genomes. We …
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins,
which have an impact on cell differentiation, gene regulation and other key cellular …
which have an impact on cell differentiation, gene regulation and other key cellular …
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
We used a collection of 708 prospectively collected autopsied brains to assess the methylation
state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of …
state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of …