Resistance to aromatase inhibitors (AIs) is a major clinical problem in the treatment of
estrogen receptor (ER)–positive breast cancer. In two breast cancer cell line models of AI …

Activation of estrogen receptor α (ERα) results in both induction and repression of gene
transcription; while mechanistic details of estrogen induction are well described, details of …

Following the worldwide emergence of the p.Asp614Gly shift in the Spike (S) gene of SARS-CoV-2,
there have been few recurring pathogenic shifts occurring during 2020, as assessed …

Diagnostic testing of pancreatic cyst fluid obtained by endoscopic ultrasound-guided fine
needle aspiration (EUS-FNA) has traditionally utilized elevated carcinoembryonic antigen (CEA…

The examination of scaffold attachment factor B1 (SAFB1) and its multiple functions and tasks
in cellular processes provides insight into its role in diseases, such as cancer. SAFB1 is a …

Transcription of the HER2 oncogene can be repressed by estrogen (E2). We now show that,
a splice isoform of the nuclear receptor coactivator AIB1, AIB1-Δ4, is able to reverse E2 …

Sumoylation is an emerging modification associated with a variety of cellular processes
including the regulation of transcriptional activities of nuclear receptors and their coregulators. …

The oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is a
transcriptional coactivator that is overexpressed in various types of human cancers. However, the …

Scaffold attachment factors SAFB1 and SAFB2 are multifunctional proteins that share >70%
sequence similarity. SAFB1-knockout (SAFB1 −/− ) mice display a high degree of lethality, …

Introduction: During the past decade, much insight has been gained regarding the
mechanisms underlying the dynamic interplay between immune cells and tumor progression. A …