User profiles for Jason K. Perry
 | Jason K PerryGilead Sciences Verified email at gilead.com Cited by 14824 |
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
Unlike other methods for docking ligands to the rigid 3D structure of a known protein receptor,
Glide approximates a complete systematic search of the conformational, orientational, and …
Glide approximates a complete systematic search of the conformational, orientational, and …
[HTML][HTML] Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
…, EP Tchesnokov, E Woolner, JK Perry… - Journal of Biological …, 2020 - ASBMB
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to
control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-…
control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-…
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
The nucleoside analog remdesivir (RDV) is a Food and Drug Administration–approved
antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
[PDF][PDF] Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the …
the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the …
Structural basis for RNA replication by the hepatitis C virus polymerase
TC Appleby, JK Perry, E Murakami, O Barauskas… - Science, 2015 - science.org
Nucleotide analog inhibitors have shown clinical success in the treatment of hepatitis C virus
(HCV) infection, despite an incomplete mechanistic understanding of NS5B, the viral RNA-…
(HCV) infection, despite an incomplete mechanistic understanding of NS5B, the viral RNA-…
[HTML][HTML] Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
Remdesivir (RDV) is a direct-acting antiviral agent that is used to treat patients with severe
coronavirus disease 2019 (COVID-19). RDV targets the viral RNA-dependent RNA …
coronavirus disease 2019 (COVID-19). RDV targets the viral RNA-dependent RNA …
[HTML][HTML] Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex
The SARS-CoV-2 nonstructural proteins coordinate genome replication and gene expression.
Structural analyses revealed the basis for coupling of the essential nsp13 helicase with …
Structural analyses revealed the basis for coupling of the essential nsp13 helicase with …
Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants
Genetic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
resulted in the emergence and rapid spread of multiple variants throughout the pandemic, of …
resulted in the emergence and rapid spread of multiple variants throughout the pandemic, of …
Antiferromagnetic band structure of Becke-3–Lee-Yang-Parr calculations
JK Perry, J Tahir-Kheli, WA Goddard III - Physical Review B, 2001 - APS
Using the Becke-3–Lee-Yang-Parr (B3LYP) functional, we have performed band-structure
calculations on the high-temperature superconductor parent compound, La 2 CuO 4. Under …
calculations on the high-temperature superconductor parent compound, La 2 CuO 4. Under …
Discovery of GS-9688 (Selgantolimod) as a potent and selective oral toll-like receptor 8 agonist for the treatment of chronic hepatitis B
RL Mackman, M Mish, G Chin, JK Perry… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to
trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with …
trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with …