Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation,
migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of …

We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in
DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG …

Disrupted ERK1/2 (MAPK3/MAPK1) MAPK signaling has been associated with several
developmental syndromes in humans; however, mutations in ERK1 or ERK2 have not been …

Deletion of UBE3A causes the neurodevelopmental disorder Angelman syndrome (AS), while
duplication or triplication of UBE3A is linked to autism. These genetic findings suggest that …

We have defined functions of MEK in regulating gliogenesis in developing cerebral cortex
using loss- and gain-of-function mouse genetics. Radial progenitors deficient in both Mek1 …

The dependence of developing spinal motoneuron survival on a soluble factor(s) from their
target, muscle tissue is well established both in vivo and in vitro. Considering this apparent …

Alternative polyadenylation (APA) is observed in virtually all metazoans and results in mRNA
isoforms with different 3’ends. It is routinely... mRNA expression dynamics promote and …

Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …

10.7554/eLife.11123.001 Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK)
pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' …

The development of effective therapeutics for brain disorders is challenging, in particular,
the blood-brain barrier (BBB) severely limits access of the therapeutics into the brain …