[HTML][HTML] Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
…, R Monroe, SE Warren, P Danaher, JW Reeves… - Nature …, 2020 - nature.com
The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to …
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to …
[HTML][HTML] Spatially organized multicellular immune hubs in human colorectal cancer
…, KH Xu, SX Chao, DR Zollinger, DJ Lieb, JW Reeves… - Cell, 2021 - cell.com
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …
[HTML][HTML] The spatial landscape of lung pathology during COVID-19 progression
Recent studies have provided insights into the pathology of and immune response to COVID-19
1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . However, a thorough investigation of the interplay between …
1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . However, a thorough investigation of the interplay between …
Subgrade resilient modulus correction for saturation effects
EC Drumm, JS Reeves, MR Madgett… - Journal of Geotechnical …, 1997 - ascelibrary.org
Mechanistic design methods for flexible pavement require the specification of the resilient
modulus M r for each soil subgrade encountered in the pavement project. The resilient …
modulus M r for each soil subgrade encountered in the pavement project. The resilient …
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
…, J Pfiffner-Borges, CJ Pinto, J Plaisted, J Reeves… - Nature, 2021 - nature.com
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
…, JA Guo, HI Hoffman, P Yadollahpour, JW Reeves… - Nature …, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer.
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …
[PDF][PDF] Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
…, TD Hether, L Marcelis, A Nam, L Pan, JW Reeves… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. …
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. …
[HTML][HTML] Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug …
…, BW Langhorst, NA Tanner, Y Kim, JW Reeves… - Nature …, 2021 - nature.com
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
killed over a million people, including >25,000 in New York City (NYC) alone. The …
killed over a million people, including >25,000 in New York City (NYC) alone. The …
[PDF][PDF] The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer
…, PMK Westcott, TD Hether, P Divakar, JW Reeves… - Cancer cell, 2021 - cell.com
The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-…
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-…
[HTML][HTML] Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression …
M Lampa, H Arlt, T He, B Ospina, J Reeves, B Zhang… - PloS one, 2017 - journals.plos.org
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize
additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (…
additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (…