The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and
the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA …

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …

Complex organisms require tissue-specific transcriptional programs, yet little is known about
how these are established. The transcription factor FoxA1 is thought to contribute to gene …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast
cancer. The completion of the human genome has allowed the identification of the …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent
marks its lethal progression. The androgen receptor (AR) is essential in both, …

Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the
genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). …

This study examined correlates of pornography acceptance and use within a normative (nonclinical)
population of emerging adults (individuals aged 18—26). Participants included 813 …

Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα)
function and breast cancer prognosis. Here we show that PR is not merely an ERα-…