User profiles for Jason T George
Jason T. GeorgeAssistant Professor, Department of Biomedical Engineering, Texas A&M University Verified email at tamu.edu Cited by 1255 |
Survival outcomes in cancer patients predicted by a partial EMT gene expression scoring metric
Metastasis is a significant contributor to morbidity and mortality for many cancer patients and
remains a major obstacle for effective treatment. In many tissue types, metastasis is fueled …
remains a major obstacle for effective treatment. In many tissue types, metastasis is fueled …
NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype
The epithelial-mesenchymal transition (EMT) is a key process implicated in cancer metastasis
and therapy resistance. Recent studies have emphasized that cells can undergo partial …
and therapy resistance. Recent studies have emphasized that cells can undergo partial …
Spleen tyrosine kinase–mediated autophagy is required for epithelial–mesenchymal plasticity and metastasis in breast cancer
These findings present inhibition of spleen tyrosine kinase as a therapeutic option to limit
breast cancer metastasis by promoting systemic tumor dormancy. See related commentary by …
breast cancer metastasis by promoting systemic tumor dormancy. See related commentary by …
[HTML][HTML] Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum
The Epithelial–mesenchymal transition (EMT) is a cellular process implicated in embryonic
development, wound healing, and pathological conditions such as cancer metastasis and …
development, wound healing, and pathological conditions such as cancer metastasis and …
Ultra-strong thermoresponsive double network hydrogels
R Fei, JT George, J Park, AK Means, MA Grunlan - Soft Matter, 2013 - pubs.rsc.org
Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels are widely studied
smart materials, particularly for biomedical applications, but are limited by their mechanical …
smart materials, particularly for biomedical applications, but are limited by their mechanical …
Differential contributions of pre-and post-EMT tumor cells in breast cancer metastasis
These findings confirm the fidelity and sensitivity of the EMT lineage tracing (Tri-PyMT)
model and highlight the differential contributions of pre- and post-EMT tumor cells in breast …
model and highlight the differential contributions of pre- and post-EMT tumor cells in breast …
[HTML][HTML] Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer
Aberrant activation of epithelial-mesenchymal transition (EMT) in carcinoma cells
contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating …
contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating …
[HTML][HTML] Computational modeling of the crosstalk between macrophage polarization and tumor cell plasticity in the tumor microenvironment
Tumor microenvironments contain multiple cell types interacting among one another via
different signaling pathways. Furthermore, both cancer cells and different immune cells can …
different signaling pathways. Furthermore, both cancer cells and different immune cells can …
E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
…, AJ Hish, S Bartholf DeWitt, JT George… - Molecular Cancer …, 2019 - AACR
… All data were analyzed for statistically significant differences using the Student t test (for
two comparisons) or ANOVA with Tukey post hoc correction (for multiple comparisons) in JMP …
two comparisons) or ANOVA with Tukey post hoc correction (for multiple comparisons) in JMP …
Epigenetic memory acquired during long-term EMT induction governs the recovery to the epithelial state
…, S Ranganathan, JT George… - Journal of the …, 2023 - royalsocietypublishing.org
Epithelial–mesenchymal transition (EMT) and its reverse mesenchymal–epithelial transition
(MET) are critical during embryonic development, wound healing and cancer metastasis. …
(MET) are critical during embryonic development, wound healing and cancer metastasis. …