User profiles for Jason T George

Jason T. George

Assistant Professor, Department of Biomedical Engineering, Texas A&M University
Verified email at tamu.edu
Cited by 1255

Survival outcomes in cancer patients predicted by a partial EMT gene expression scoring metric

JT George, MK Jolly, S Xu, JA Somarelli, H Levine - Cancer research, 2017 - AACR
Metastasis is a significant contributor to morbidity and mortality for many cancer patients and
remains a major obstacle for effective treatment. In many tissue types, metastasis is fueled …

NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype

…, SC Tripathi, SA Vilchez Mercedes, JT George… - Integrative …, 2019 - academic.oup.com
The epithelial-mesenchymal transition (EMT) is a key process implicated in cancer metastasis
and therapy resistance. Recent studies have emphasized that cells can undergo partial …

Spleen tyrosine kinase–mediated autophagy is required for epithelial–mesenchymal plasticity and metastasis in breast cancer

…, JC Anderson, RB Khodadadi, WS Brown, JT George… - Cancer research, 2019 - AACR
These findings present inhibition of spleen tyrosine kinase as a therapeutic option to limit
breast cancer metastasis by promoting systemic tumor dormancy. See related commentary by …

[HTML][HTML] Comparative study of transcriptomics-based scoring metrics for the epithelial-hybrid-mesenchymal spectrum

P Chakraborty, JT George, S Tripathi… - … in bioengineering and …, 2020 - frontiersin.org
The Epithelial–mesenchymal transition (EMT) is a cellular process implicated in embryonic
development, wound healing, and pathological conditions such as cancer metastasis and …

Ultra-strong thermoresponsive double network hydrogels

R Fei, JT George, J Park, AK Means, MA Grunlan - Soft Matter, 2013 - pubs.rsc.org
Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels are widely studied
smart materials, particularly for biomedical applications, but are limited by their mechanical …

Differential contributions of pre-and post-EMT tumor cells in breast cancer metastasis

…, D Ramchandani, W Du, O Elemento, JT George… - Cancer research, 2020 - AACR
These findings confirm the fidelity and sensitivity of the EMT lineage tracing (Tri-PyMT)
model and highlight the differential contributions of pre- and post-EMT tumor cells in breast …

[HTML][HTML] Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

…, D Jia, JT George, SM Hanash, T Brabletz… - APL …, 2018 - pubs.aip.org
Aberrant activation of epithelial-mesenchymal transition (EMT) in carcinoma cells
contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating …

[HTML][HTML] Computational modeling of the crosstalk between macrophage polarization and tumor cell plasticity in the tumor microenvironment

X Li, MK Jolly, JT George, KJ Pienta, H Levine - Frontiers in oncology, 2019 - frontiersin.org
Tumor microenvironments contain multiple cell types interacting among one another via
different signaling pathways. Furthermore, both cancer cells and different immune cells can …

E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms

…, AJ Hish, S Bartholf DeWitt, JT George… - Molecular Cancer …, 2019 - AACR
… All data were analyzed for statistically significant differences using the Student t test (for
two comparisons) or ANOVA with Tukey post hoc correction (for multiple comparisons) in JMP …

Epigenetic memory acquired during long-term EMT induction governs the recovery to the epithelial state

…, S Ranganathan, JT George… - Journal of the …, 2023 - royalsocietypublishing.org
Epithelial–mesenchymal transition (EMT) and its reverse mesenchymal–epithelial transition
(MET) are critical during embryonic development, wound healing and cancer metastasis. …