User profiles for Jason Town

Jason P Town

University of California San Francisco
Verified email at ucsf.edu
Cited by 240

Carbon dots for carbon dummies: the quantum and the molecular questions among some others

R de Boëver, JR Town, X Li… - Chemistry–A European …, 2022 - Wiley Online Library
Carbon Dots (CDs) are carbon nanoparticles which were discovered in 2004. Despite two
decades of intensive work from the scientific community and a colossal amount of gathered …

[PDF][PDF] Cell protrusions and contractions generate long-range membrane tension propagation

H De Belly, S Yan, HB da Rocha, S Ichbiah, JP Town… - Cell, 2023 - cell.com
Membrane tension is thought to be a long-range integrator of cell physiology. Membrane
tension has been proposed to enable cell polarity during migration through front-back …

The WAVE complex associates with sites of saddle membrane curvature

A Pipathsouk, RM Brunetti, JP Town… - Journal of Cell …, 2021 - rupress.org
How local interactions of actin regulators yield large-scale organization of cell shape and
movement is not well understood. Here we investigate how the WAVE complex organizes sheet…

[HTML][HTML] Cell confinement reveals a branched-actin independent circuit for neutrophil polarity

BR Graziano, JP Town, E Sitarska, TL Nagy… - PLoS …, 2019 - journals.plos.org
Migratory cells use distinct motility modes to navigate different microenvironments, but it is
unclear whether these modes rely on the same core set of polarity components. To investigate …

Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration

S Saha, JP Town, OD Weiner - Molecular biology of the cell, 2023 - Am Soc Cell Biol
By acting both upstream of and downstream from biochemical organizers of the cytoskeleton,
physical forces function as central integrators of cell shape and movement. Here we use a …

State-of-the-art cooling technology for a turbine rotor blade

J Town, D Straub, J Black… - Journal of …, 2018 - asmedigitalcollection.asme.org
Effective internal and external cooling of airfoils is key to maintaining component life for
efficient gas turbines. Cooling designs have spanned the range from simple internal convective …

A toolkit for rapid modular construction of biological circuits in mammalian cells

…, AR Bonny, GR Kumar, AH Ng, J Town… - ACS synthetic …, 2019 - ACS Publications
The ability to rapidly assemble and prototype cellular circuits is vital for biological research
and its applications in biotechnology and medicine. Current methods for the assembly of …

Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

DM Britain, JP Town, OD Weiner - Elife, 2022 - elifesciences.org
T cells use kinetic proofreading to discriminate antigens by converting small changes in
antigen-binding lifetime into large differences in cell activation, but where in the signaling …

[HTML][HTML] Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance

JP Town, OD Weiner - PLoS Biology, 2023 - journals.plos.org
To migrate efficiently, neutrophils must polarize their cytoskeletal regulators along a single
axis of motion. This polarization process is thought to be mediated through local positive …

Actin-driven protrusions generate rapid long-range membrane tension propagation in cells

H De Belly, S Yan, HB da Rocha, S Ichbiah, JP Town… - bioRxiv, 2022 - biorxiv.org
Membrane tension is thought to be a long-range integrator of cell physiology. This role
necessitates effective tension transmission across the cell. However, the field remains strongly …