[PDF][PDF] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19)…
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19)…
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
…, B Meyer, M Vignuzzi, D Missiakas, JW Botten… - Science, 2021 - science.org
There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …
[HTML][HTML] Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step
The ongoing COVID-19 pandemic has created an unprecedented need for rapid diagnostic
testing. The World Health Organization (WHO) recommends a standard assay that includes …
testing. The World Health Organization (WHO) recommends a standard assay that includes …
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples
…, KR Jerome, AL Greninger, JW Botten - EMBO Molecular …, 2022 - embopress.org
With the COVID‐19 pandemic caused by SARS‐CoV‐2 now in its second year, there remains
an urgent need for diagnostic testing that can identify infected individuals, particularly …
an urgent need for diagnostic testing that can identify infected individuals, particularly …
SARS-CoV-2 triggers DNA damage response in Vero E6 cells
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible
for the current COVID-19 pandemic and has now infected more than 200 million people …
for the current COVID-19 pandemic and has now infected more than 200 million people …
[PDF][PDF] The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles
Arenaviruses and hantaviruses cause severe human disease. Little is known regarding host
proteins required for their propagation. We identified human proteins that interact with the …
proteins required for their propagation. We identified human proteins that interact with the …
[HTML][HTML] Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge …
Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The
current lack of an effective vaccine to simultaneously protect against the four serotypes of …
current lack of an effective vaccine to simultaneously protect against the four serotypes of …
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro
…, MÁ Muñoz-Alía, B Schuster, V Nair, JW Botten… - BioRxiv, 2020 - biorxiv.org
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest
path to clinical use is repurposing of drugs that have an established safety profile in humans. …
path to clinical use is repurposing of drugs that have an established safety profile in humans. …
'All In': a pragmatic framework for COVID‐19 testing and action on a global scale
…, S Hester, L Wehmas, JW Botten… - EMBO Molecular …, 2020 - embopress.org
Current demand for SARS ‐CoV‐2 testing is straining material resource and labor capacity
around the globe. As a result, the public health and clinical community are hindered in their …
around the globe. As a result, the public health and clinical community are hindered in their …
Kinetics and isotype assessment of antibodies targeting the spike protein receptor‐binding domain of severe acute respiratory syndrome‐coronavirus‐2 in COVID‐19 …
…, E van den Broek‐Altenburg, JW Botten… - Clinical & …, 2020 - Wiley Online Library
Objectives There is an incomplete understanding of the host humoral immune response to
severe acute respiratory syndrome (SARS)‐coronavirus (CoV)‐2, which underlies COVID‐19, …
severe acute respiratory syndrome (SARS)‐coronavirus (CoV)‐2, which underlies COVID‐19, …