[PDF][PDF] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses

…, G De Lorenzo, SJ Rihn, RM Voorhees, JW Botten… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19)…

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2

…, B Meyer, M Vignuzzi, D Missiakas, JW Botten… - Science, 2021 - science.org
There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …

[HTML][HTML] Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step

…, JA Dragon, JW Crothers, KR Jerome, JW Botten - PLoS …, 2020 - journals.plos.org
The ongoing COVID-19 pandemic has created an unprecedented need for rapid diagnostic
testing. The World Health Organization (WHO) recommends a standard assay that includes …

Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples

…, KR Jerome, AL Greninger, JW Botten - EMBO Molecular …, 2022 - embopress.org
With the COVID‐19 pandemic caused by SARS‐CoV‐2 now in its second year, there remains
an urgent need for diagnostic testing that can identify infected individuals, particularly …

SARS-CoV-2 triggers DNA damage response in Vero E6 cells

…, EN Lamkin, A March, P Zhou, JW Botten… - Biochemical and …, 2021 - Elsevier
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible
for the current COVID-19 pandemic and has now infected more than 200 million people …

[PDF][PDF] The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles

…, L Liao, JR Yates, B Zhang, BA Ballif, JW Botten - Cell host & …, 2013 - cell.com
Arenaviruses and hantaviruses cause severe human disease. Little is known regarding host
proteins required for their propagation. We identified human proteins that interact with the …

[HTML][HTML] Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge …

…, A Sette, D Weiskopf, JE Boyson, JW Botten - Frontiers in …, 2020 - frontiersin.org
Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious human disease. The
current lack of an effective vaccine to simultaneously protect against the four serotypes of …

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

…, MÁ Muñoz-Alía, B Schuster, V Nair, JW Botten… - BioRxiv, 2020 - biorxiv.org
There is an urgent need for anti-viral agents that treat SARS-CoV-2 infection. The shortest
path to clinical use is repurposing of drugs that have an established safety profile in humans. …

'All In': a pragmatic framework for COVID‐19 testing and action on a global scale

…, S Hester, L Wehmas, JW Botten… - EMBO Molecular …, 2020 - embopress.org
Current demand for SARS ‐CoV‐2 testing is straining material resource and labor capacity
around the globe. As a result, the public health and clinical community are hindered in their …

Kinetics and isotype assessment of antibodies targeting the spike protein receptor‐binding domain of severe acute respiratory syndrome‐coronavirus‐2 in COVID‐19 …

…, E van den Broek‐Altenburg, JW Botten… - Clinical & …, 2020 - Wiley Online Library
Objectives There is an incomplete understanding of the host humoral immune response to
severe acute respiratory syndrome (SARS)‐coronavirus (CoV)‐2, which underlies COVID‐19, …