[HTML][HTML] Spatially organized multicellular immune hubs in human colorectal cancer
…, KH Xu, SX Chao, DR Zollinger, DJ Lieb, JW Reeves… - Cell, 2021 - cell.com
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
…, JA Guo, HI Hoffman, P Yadollahpour, JW Reeves… - Nature …, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer.
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …
[PDF][PDF] Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
…, TD Hether, L Marcelis, A Nam, L Pan, JW Reeves… - Cell, 2021 - cell.com
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. …
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. …
[HTML][HTML] Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
…, R Monroe, SE Warren, P Danaher, JW Reeves… - Nature …, 2020 - nature.com
The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to …
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to …
[HTML][HTML] Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug …
…, BW Langhorst, NA Tanner, Y Kim, JW Reeves… - Nature …, 2021 - nature.com
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
killed over a million people, including >25,000 in New York City (NYC) alone. The …
killed over a million people, including >25,000 in New York City (NYC) alone. The …
[PDF][PDF] The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer
…, PMK Westcott, TD Hether, P Divakar, JW Reeves… - Cancer cell, 2021 - cell.com
The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-…
and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-…
[HTML][HTML] Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler
…, EA Mittendorf, J Perez, A Prat, L Pusztai, JW Reeves… - Cancers, 2021 - mdpi.com
Simple Summary In breast cancer, there is a high degree of variability in tumors and the
surrounding tissue called the tumor microenvironment (TME). To better understand tumor …
surrounding tissue called the tumor microenvironment (TME). To better understand tumor …
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
The organization of immune cells in human tumors is not well understood. Immunogenic tumors
harbor spatially localized multicellular ‘immunity hubs’ defined by expression of the T cell…
harbor spatially localized multicellular ‘immunity hubs’ defined by expression of the T cell…
[HTML][HTML] Comprehensive analysis of cutaneous and uveal melanoma liver metastases
…, A Broeks, RM Kerkhoven, JW Reeves… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background The profound disparity in response to immune checkpoint blockade (ICB) by
cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. …
cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. …
Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response
The organization of immune cells in human tumors is not well understood. Immunogenic
tumors harbor spatially-localized multicellular ‘immunity hubs’ defined by expression of the T …
tumors harbor spatially-localized multicellular ‘immunity hubs’ defined by expression of the T …