Background DNA methylation changes with age. Chronological age predictors built from DNA
methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual …

An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently
needed because the number of affected individuals is projected to increase rapidly as …

Importance Genome-wide association studies (GWASs) in European populations have
identified more than 100 schizophrenia-associated loci. A schizophrenia GWAS in a unique …

Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular
disease and stroke. Essential hypertension (EH), a polygenic condition, has also been …

Introduction Family based study designs provide an informative resource to identify disease-causing
mutations. The Queensland Parkinson's Project (QPP) has been involved in …

Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous
system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by …

Despite the success of genome-wide association studies (GWAS) in detecting genetic loci
involved in complex traits, few susceptibility genes have been detected for essential …

DNA methylation is associated with age. The deviation of age predicted from DNA
methylation from actual age has been proposed as a biomarker for ageing. However, a better …

Parkinson’s disease (PD) is typically sporadic; however, multi-incident families provide a
powerful platform to discover novel genetic forms of disease. Their identification supports …

Migraine is the most common neurological disorder worldwide affecting about 12% of the
worldwide population. This disorder has been classed into two main types of migraine—with …