Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that the …

Antimicrobial resistance (AMR) in bacteria is a major threat to public health; one of the key
elements in the spread and evolution of AMR in clinical pathogens is the transfer of …

Infections caused by carbapenemase-producing enterobacteria (CPE) are a major concern
in clinical settings worldwide. Two fundamentally different processes shape the …

Plasmid persistence in bacterial populations is strongly influenced by the fitness effects
associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial hosts …

Conjugative plasmids play a key role in the dissemination of antimicrobial resistance (AMR)
genes across bacterial pathogens. AMR plasmids are widespread in clinical settings, but …

Understanding the mechanisms governing innovation is a central element of evolutionary
theory. Novel traits usually arise through mutations in existing genes, but trade-offs between …

Antimicrobial resistance (AMR) in bacteria is a major public health problem. The main route
for AMR acquisition in clinically important bacteria is the horizontal transfer of plasmids …

Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative
plasmids play a key role in the dissemination of AMR genes among bacterial pathogens. …

Mobile genetic elements such as plasmids mediate horizontal gene transfer in prokaryotes,
promoting bacterial adaptation and evolution. Despite the potential advantages conferred by …

Objectives To investigate the fitness effects of large bla CTX-M-15 -harbouring F2:A1:B−
plasmids on their native Escherichia coli ST131 H30Rx hosts. Methods We selected five E. coli …