Internal ribosome entry site (IRES) elements were discovered in picornaviruses. These
elements are cis-acting RNA sequences that adopt diverse three-dimensional structures and …

Internal ribosome entry site (IRES) elements are cis-acting RNA regions that promote internal
initiation of protein synthesis using cap-independent mechanisms. However, distinct types …

RNA-binding proteins (RBPs) play crucial roles in all organisms. The protein Gemin5
harbors two functional domains. The N-terminal domain binds to snRNAs targeting them for …

RNA-binding proteins (RBPs) are pivotal regulators of all the steps of gene expression.
RBPs govern gene regulation at the post-transcriptional level by virtue of their capacity to …

Ribonucleic acid (RNA)-binding proteins are key players of gene expression control. We
have shown that Gemin5 interacts with internal ribosome entry site (IRES) elements and …

In all organisms, a selected type of proteins accomplishes critical roles in cellular processes
that govern gene expression. The multifunctional protein Gemin5 cooperates in translation …

Gemin5 is a RNA-binding protein (RBP) that was first identified as a peripheral component
of the survival of motor neurons (SMN) complex. This predominantly cytoplasmic protein …

Improvements in Systematic Evolution of Ligands by EXponential enrichment (SELEX)
technology and DNA sequencing methods have led to the identification of a large number of …

Gemin5 is a predominantly cytoplasmic protein that downregulates translation, beyond
controlling snRNPs assembly. The C-terminal region harbors a non-canonical RNA-binding site …

Translation control often takes place through the mRNA untranslated regions, involving
direct interactions with RNA-binding proteins (RBPs). Internal ribosome entry site elements (…