The function of the CCCTC-binding factor (CTCF) in the organization of the genome has
become an important area of investigation, but the mechanisms by which CTCF dynamically …

Highly coordinated changes in gene expression underlie T cell activation and exhaustion.
However, the mechanisms by which such programs are regulated and how these may be …

Investigating how chromatin organization determines cell-type-specific gene expression
remains challenging. Experimental methods for measuring three-dimensional chromatin …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …

CTCF and cohesin play a key role in organizing chromatin into topologically associating
domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change …

Background Ubiquitously expressed CTCF is involved in numerous cellular functions, such
as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only …

Butyrivibrio fibrisolvens forms part of the gastrointestinal microbiome of ruminants and other
mammals, including humans. Indeed, it is one of the most common bacteria found in the …

The mammalian genome is spatially organized in the nucleus to enable cell type-specific
gene 17 expression. Investigating how chromatin architecture determines this specificity …

The function of the CCCTC-binding factor (CTCF) in the organization of the genome has
become an important area of investigation, but the mechanisms of how CTCF dynamically …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages, the trophectoderm (TE), the epiblast (EPI) and the …