Large-scale surveys of single-cell gene expression have the potential to reveal rare cell
populations and lineage relationships but require efficient methods for cell capture and mRNA …

In the developing human neocortex, progenitor cells generate diverse cell types prenatally.
Progenitor cells and newborn neurons respond to signaling cues, including neurotransmitters…

The design, fabrication, and demonstration of a hand-held microchip-based analytical
instrument for detection and identification of proteins and other biomolecules are reported. The …

Current OSHA standards for naphthalene exposure are set at 10 ppm (time-weighted average)
with a standard threshold exposure concentration of 15 ppm. While several studies have …

Efficient and rapid isolation of mRNA is important in the field of genomics as well as in the
clinical and pharmaceutical arena. We have developed UV-initiated methacrylate-based …

We report the development of a hand‐held instrument capable of performing two simultaneous
microchip separations (gel and zone electrophoresis), and demonstrate this instrument …

Repeated exposures to Clara cell cytotoxicants, such as naphthalene (NA), render target
cell populations resistant to further acute injury. Previous studies suggest that alterations in …

The study of single cells has evolved over the past several years to include expression and
genomic analysis of an increasing number of single cells. Several studies have …

Repeated exposures to bioactivated cytotoxicants such as naphthalene (NA) render the
target population, Clara cells, resistant to further injury through a glutathione-dependent …

Clara-cell populations show a high degree of variation in susceptibility to injury by bioactivated
cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic …