User profiles for Jay A.A. West
Jay AA West, PhDBioskryb Verified email at bioskryb.com Cited by 5314 |
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell
populations and lineage relationships but require efficient methods for cell capture and mRNA …
populations and lineage relationships but require efficient methods for cell capture and mRNA …
[PDF][PDF] Multimodal single-cell analysis reveals physiological maturation in the developing human neocortex
…, ML Gonzales, L Szpankowski, A Leyrat, JAA West… - Neuron, 2019 - cell.com
In the developing human neocortex, progenitor cells generate diverse cell types prenatally.
Progenitor cells and newborn neurons respond to signaling cues, including neurotransmitters…
Progenitor cells and newborn neurons respond to signaling cues, including neurotransmitters…
Hand-held microanalytical instrument for chip-based electrophoretic separations of proteins
The design, fabrication, and demonstration of a hand-held microchip-based analytical
instrument for detection and identification of proteins and other biomolecules are reported. The …
instrument for detection and identification of proteins and other biomolecules are reported. The …
Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats
JAA West, G Pakehham, D Morin, CA Fleschner… - Toxicology and applied …, 2001 - Elsevier
Current OSHA standards for naphthalene exposure are set at 10 ppm (time-weighted average)
with a standard threshold exposure concentration of 15 ppm. While several studies have …
with a standard threshold exposure concentration of 15 ppm. While several studies have …
Microfluidic purification and preconcentration of mRNA by flow-through polymeric monolith
…, S Stern, MR Caplan, KW Hukari, JAA West - Analytical …, 2007 - ACS Publications
Efficient and rapid isolation of mRNA is important in the field of genomics as well as in the
clinical and pharmaceutical arena. We have developed UV-initiated methacrylate-based …
clinical and pharmaceutical arena. We have developed UV-initiated methacrylate-based …
Microchip separations of protein biotoxins using an integrated hand‐held device
We report the development of a hand‐held instrument capable of performing two simultaneous
microchip separations (gel and zone electrophoresis), and demonstrate this instrument …
microchip separations (gel and zone electrophoresis), and demonstrate this instrument …
Elevated airway GSH resynthesis confers protection to Clara cells from naphthalene injury in mice made tolerant by repeated exposures
JAA West, AR Buckpitt, CG Plopper - Journal of pharmacology and …, 2000 - ASPET
Repeated exposures to Clara cell cytotoxicants, such as naphthalene (NA), render target
cell populations resistant to further acute injury. Previous studies suggest that alterations in …
cell populations resistant to further acute injury. Previous studies suggest that alterations in …
[HTML][HTML] Fluidic logic used in a systems approach to enable integrated single-cell functional analysis
…, KJ Livak, C Larsen, M Unger, JAA West - … in bioengineering and …, 2016 - frontiersin.org
The study of single cells has evolved over the past several years to include expression and
genomic analysis of an increasing number of single cells. Several studies have …
genomic analysis of an increasing number of single cells. Several studies have …
Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice
JAA West, LS Van Winkle, D Morin… - Toxicological …, 2003 - academic.oup.com
Repeated exposures to bioactivated cytotoxicants such as naphthalene (NA) render the
target population, Clara cells, resistant to further injury through a glutathione-dependent …
target population, Clara cells, resistant to further injury through a glutathione-dependent …
Heterogeneity of Clara cell glutathione: a possible basis for differences in cellular responses to pulmonary cytotoxicants
JAA West, CH Chichester, AR Buckpitt… - American journal of …, 2000 - atsjournals.org
Clara-cell populations show a high degree of variation in susceptibility to injury by bioactivated
cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic …
cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic …