Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

The low rate of homologous recombination exhibited by wild-type strains of filamentous fungi
has hindered development of high-throughput gene knockout procedures for this group of …

Provides a comprehensive textbook for use in biological rhythms courses at both the
advanced undergraduate and graduate levels and provides a nontechnical source book for …

To understand how light might entrain a mammalian circadian clock, we examined the effects
of light on mPer1, a sequence homolog of Drosophila per, that exhibits robust rhythmic …

We present an analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the
genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of …

The frequency (frq) locus of Neurospora crassa was originally identified in searches for loci
encoding components of the circadian clock. The frq gene is now shown to encode a central …

In the fungus Neurospora crassa, the blue light photoreceptor(s) and signaling pathway(s)
have not been identified. We examined light signaling by exploiting the light sensitivity of the …

Circadian rhythmicity is universally associated with the ability to perceive light, and the oscillators
(“clocks”) giving rise to these rhythms, which are feedback loops based on transcription …

The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating
of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, …

In Neurospora crassa, white collar 1 (WC-1), a transcriptional activator and positive clock
element, is rhythmically expressed from a nonrhythmic steady-state pool of wc-1transcript, …