Methods for quantifying gene expression 1 and chromatin accessibility 2 in single cells are
well established, but single-cell analysis of chromatin regions with specific histone …

Aggressive cancers often have activating mutations in growth-controlling oncogenes and
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …

Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving
the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed-…

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic
of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly …

Background Our understanding of eukaryotic gene regulation is limited by the complexity of
protein–DNA interactions that comprise the chromatin landscape and by inefficient methods …

This study provides insights into the dynamics of nucleosome positioning and gene regulation
associated with cancer phenotypes that can be ascertained from ctDNA. New methods for …

The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive
CD8 + T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is necessary …

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by a nucleotide
excision repair deficit, resulting in sensitivity to UV radiation. 1 Individuals with XP are …

Purpose: Propagation of Ewing sarcoma requires precise regulation of EWS::FLI1
transcriptional activity. Determining the mechanisms of fusion regulation will advance our …

Cancer accounts for ∼9 million deaths per year worldwide, predominantly affecting adults.
Adult malignancies are usually examined after extensive clonal evolution and carry many …