Pediatric neuroimaging studies 1, 2, 3, 4, 5, up to now exclusively cross sectional, identify
linear decreases in cortical gray matter and increases in white matter across ages 4 to 20. In …

Advances in neuroimaging have ushered in a new era of developmental neuroscience.
Magnetic resonance imaging (MRI) is particularly well suited for pediatric studies because it …

We report the dynamic anatomical sequence of human cortical gray matter development
between the age of 4–21 years using quantitative four-dimensional maps and time-lapse …

Few parents of a teenager are surprised to hear that the brain of a 16-year-old is different
from the brain of an 8-year-old. Yet to pin down these differences in a rigorous scientific way …

Despite significant gains in the fields of pediatric neuroimaging and developmental neurobiology,
surprisingly little is known about the developing human brain or the neural bases of …

Magnetic resonance imaging (MRI) provides accurate anatomical brain images without the
use of ionizing radiation, allowing longitudinal studies of brain morphometry during …

… The raters were trained at the image analysis laboratory of NIH (Jay Giedd, MD) or at
WPIC/UPMC (Matcheri S. Keshavan, MD). Methodological details are provided elsewhere (see …

The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable
physical and behavioural changes. The processes in the brain that underlie these …

ContextVarious anatomic brain abnormalities have been reported for attention-deficit/hyperactivity
disorder (ADHD), with varying methods, small samples, cross-sectional designs, and …

Understanding the organization of the cerebral cortex remains a central focus of neuroscience.
Cortical maps have relied almost exclusively on the examination of postmortem tissue to …